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Drugs Targeting “Zombie” Cells May Benefit Some Older Women, but Not All

Senescent cells can't divide but can drive chronic inflammation and tissue dysfunction linked to aging and chronic diseases. In a new trial, treatment with intermittent senolytic treatment had beneficial effects on bone formation.
A small molecule blocks the DNA splicing site of an enzyme.
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Small Molecules Offer New Approach for Modulating Genetic Splicing

Researchers have uncovered how small molecules can modulate genetic splicing, offering a new approach to identifying drugs that act on genetic mutations.
Cells after UV exposure.
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UV Damage Leads to Ribosomes Roadblocks, Resulting in Skin Cell Death

While UV radiation has long been known to damage DNA, it also damages mRNA, and the findings of a new study indicate that mRNAs act as first responders in telling the cells how to manage the stress.
Two scientist looking at a computer screen.
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New Method Uses Light to Induce Inflammatory Cell Death

University of Illinois researchers developed a method to precisely target cells for inflammatory cell death using light. The ability to precisely initiate this process in a small area is important for cancer and other diseases.
A close up of someone being tattooed.
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Tattoo Inks Found Contaminated with Harmful Bacteria

Researchers have detected anaerobic and aerobic bacteria in commercial tattoo and permanent makeup inks. The findings demonstrate that the inks could be a source of human infections.
Cancer cells.
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Compounds Discovered That Convert a Protein Into a “Tumor Killer”

Oregon State University researchers have discovered compounds that convert a protein known for protecting cancer cells into a tumor killer.
Cells.
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Researchers Dissect How Fluctuating Energy Sources Drive Microbial Bioproduction

In the work of biomanufacturing, tanks of microbes are fine-tuned to produce compounds that can be used as carbon-neutral fuels, chemicals, materials and medicines, but researchers are still learning the basics of how to turbo charge for production.
Cells.
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Calorie-Storing Fat Cells Can Be Turned Into Calorie-Burning Fat Cells

UCSF study finds that switching off a protein in white fat cells could open the door to developing a new class of weight-loss drugs.
Neurons degenerating.
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Uncovering Hidden Pathways in Parkinson’s Disease Progression

A pair of recent studies have uncovered previously unknown cellular mechanisms involved in neuronal protein aggregation and misfolding, key characteristics of Parkinson’s disease.
Image from an electron microscope showing how Enterococcus faecalis bacteria clump together to share, among other things, antibiotic resistance with each other.
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Understanding How Bacteria Share Antibiotic Resistance

A study provides new clues in the understanding of how antibiotic resistance spreads. The study shows how an enzyme breaks down the bacteria's protective outer layer, the cell wall, and facilitates the transfer of genes for resistance to antibiotics.
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