Advances in Flow-Through Technology To Enhance mAb Polishing
Advances in monoclonal antibody (mAb) engineering have led to additional challenges in the purification of these modalities, including high levels of aggregates. Ion exchange chromatography is often not sufficient to achieve purity targets meaning hydrophobic interaction chromatography (HIC) and mixed-mode resins are needed as orthogonal tools. These technologies can be implemented in flow-through mode allowing for high loadings and fast processing times, making them well-suited for large-scale implementation.
This webinar highlights three case studies that illustrate how novel chromatographic tools can improve the purification process for complex therapeutics by reducing the levels of aggregates and host cell proteins (HCPs) and effectively clearing retroviruses.
Attend this webinar to explore case studies on:
- Effective aggregate removal and viral clearance via HIC flow-through unit operation
- High molecular weight reduction and viral clearance for a novel, pre-conjugated mAb for ADC production
- Simultaneous HCP reduction and aggregate removal with mixed-mode chromatography for a high aggregate mAb feedstream
