The Role of Mass Spectrometry Imaging in Studying Tumor Metabolism

In tumors, metabolic shifts cause increased glucose uptake and fermentation. Traditionally, bulk analysis has been used to measure tumor metabolism, however, all tumors show some heterogeneity, and only an average measurement is produced by bulk analysis. 

The advent of MALDI Imaging is thus a major advancement in cancer biology, as the metabolism of different clones can be measured in situ.

Download this poster to discover a method that can:

• Perform metabolic flux analysis in bi-clonal tumor models
• Detect differences in metabolic activities of cells in their spatial environment
• Increase the sensitivity for the detection of TCA-cycle intermediates in MALDI Imaging