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Streamlined Detection and Characterization of Mitochondrial Toxicants

credit: iStock

Early detection of mitochondrial toxicity is critical in initial drug development efforts because mitochondrial dysfunction plays a major role in drug-induced hepatotoxicity.

While immortalized cell lines are widely used for in vitro assessment of hepatotoxicity, cryopreserved primary human hepatocytes are a preferred model for drug safety screening.

This app note highlights an assay that enables streamlined, sensitive detection and characterization of mitochondrial toxicants.

Download this app note to discover how to: 

  • Distinguish between different modes of mitochondrial toxicity with high sensitivity
  • Optimize cell seeding density and FCCP concentration
  • Determine the magnitude of toxicity

Download the Application Note for FREE Now!
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