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Modeling Neurodegenerative Diseases with Pre-formed Fibrils
The research on neurodegenerative diseases like Alzheimer's disease (AD) and Parkinson's disease (PD) relies heavily on accurate disease models. Traditional transgenic or toxin-induced mouse models often fail to replicate the natural progression of these diseases. Pre-formed Fibrils (PFFs) offer a promising alternative by mimicking the seeding and propagation of pathogenic proteins, enabling more realistic in vivo and in vitro models for diagnosing, treating, and preventing neurodegenerative diseases.
Considering the pivotal role of Tau PFFs and Alpha-Synuclein PFFs in modeling AD and PD, Aneuro's Tau and Alpha-Synuclein PFFs products undergo rigorous quality control and validation to ensure the purity, homogeneity, and endotoxin levels of the monomers meet experimental requirements. The aggregation morphology and recruitment activity of the PFFs has been thoroughly verified through electron microscopy, ThT assays, and cellular-level experiments, ensuring their stability and reproducibility in AD and PD models.
As the brand of ACROBiosystems that focuses on neuroscience, Aneuro provides Tau-441 PFFs and Alpha-Synuclein PFFs supporting and accelerating the establishment of reliable neurodegenerative models.
ACROBiosystems is a cornerstone enterprise of the pharmaceutical and biotechnology industries. Our mission is to help overcome challenges with innovative tools and solutions from discovery to the clinic. We supply life science tools designed for discovery research and scalable to the clinical phase and beyond. By consistently adapting to new regulatory challenges and guidelines, we deliver solutions, whether it comes through recombinant proteins, antibodies, assay kits, GMP-grade reagents, or custom services. We empower scientists and engineers dedicated to innovation to simplify and accelerate the development of new, better, and more affordable medicine.
Our way of addressing challenges in biologics development is to offer a comprehensive array of tools and solutions designed for each development phase. Starting from discovery and development and moving beyond commercialization, we strive to deliver high-quality solutions that support each step of the development process. This means bringing together innovation and technology through product development and collaborations to help our customers achieve translatable results in the clinic and beyond.
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