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In this study, the role of miRNAs has been assessed in a large cohort of pancreatic cancer.

We present a case of pulmonary embolism in a young man who
benefitted from point of care ultrasound. His management was
changed significantly with the results despite initial risk stratification
suggesting ambulatory management.

Our objective is to validate diagnostic services using Oxford Nanopore’s Minion in the first instance and to evaluate the cost and performance compared to existing sequencing technology in areas such as tumour DNA sequencing (and circulating tumour DNA), virology, microbiology, genetics and HLA-typing.

MHV-68 infection in our rag2 mouse model induced increased antibody responses to virus and self and inflammatory disease in end organs. Major mechanism of inflammatory infiltrates and autoantibody generation is yet to be determined

This is a rare presentation of malignant pleural mesothelioma in a young female patient with rheumatoid arthritis and no known asbestos exposure.

Here, we have identified the particular polymorphism responsible for the loss of monoclonal antibody reactivity and investigated the potential effect these polymorphisms may have on the sensitivity of the Ov16 ELISA for the detection of parasite exposure.

The Acoustic Startle Reflex (ASR) is a brain-stem mediated, tri-synaptic response to acoustic stimuli involving involuntary contraction of major muscle groups. Previous studies have demonstrated that this response is suppressed following the fluid-percussion model of traumatic brain injury (TBI). The possibility exists that the suppression of this response could be exploited for prognostic purposes.

The human immune system is comprised of a complex network of immune checkpoint receptors that are promising new immunotherapy targets for the treatment of a variety of diseases including cancer and autoimmune-mediated disorders.

Our results indicate that MS modifications are required for experiments with co-electroporation of Cas9 mRNA and synthetic gRNA, yet have no impact on editing efficiency when delivered with lipid-based transfection reagents.

The recent fast advancement of next generation sequencing (NGS) technologies allowing for unprecedented speed and accuracy in analyzing viral genomes are opening new ways to further improve diagnostic genotyping of HCV.