Latest Posters
Poster
Severe Combined Immunodeficiency (SCID) caused by thymic aplasia due to a mutation in TBX1
We report one of the first cases of TBX1 haploinsufficiency causing complete thymic aplasia and SCID.
Poster
Assessing Microenvironment Immunogenicity Using Tumor Specimen Exomes: Co-detection of TcR-α/β V(D)J Recombinations Correlates with PD-1Expression
This is the first report of any unproductive recombinations in tumor specimen exome files, indicating opportunities to identify lymphocytes in the microenvironment that could have impacts on tumor development other than via antigen presentation to T-cells. Based on α/β relative recombination rates, α recombinations are more frequent. The association of detection of alpha-beta V(D)J recombinations, with high PD-1 RNA levels and high RNA levels representing antigen presenting functions.
Poster
Comparison of CD45+ Depletion Methods for Enrichment of Disseminated Tumor Cells in Bone Marrow Samples
Comparison of CD45+ depletion methods for enrichment of disseminated tumor cells in bone marrow samples.
Poster
Improved T Cell Activation Bioassays for Development of Bispecific Antibodies and Engineered T Cell Immunotherapies
Here we describe a platform of T cell activation bioassays for the development of CD3 bispecific antibodies and engineered T cell immunotherapies.
Poster
Exploiting Polypharmacology in Precision Oncology: Identification of Differential Kinase Off-targets Among Clinical PARP Inhibitors
Can we use computational methods to identify previously unknown off-targets of PARP inhibitors that can explain their observed differences?
Poster
Validation of an Image-Based 3D Natural Killer Cell Mediated Cytotoxicity Assay
Here we describe a novel 3D NK cell mediated cytotoxicity (CMC) assay.
Poster
Immunotherapy on Chip: “Under the Microscope” Drug-induced Modulation of the Immune Response
The immune system is a striking example of an integrated information system, engaged in coordinated host-protective activities. Organs-on-chip approach (OOC) models allow the direct simultaneous observation of hundreds of different cells, moving, interacting and responding to signals coming from the microenvironment nearby, that give access to a number of parameters describing the system that must be properly measured and elaborated.
Poster
Characterizing GPCR Activation Using Automated Live Cell Imaging
Here we describe a live cell imaging based approach to detect GPCR activation using the Lionheart™ FX Automated Live Cell Imager and Gen5™ Microplate Reader and Imager Software.
Poster
MicroRNAs as Bile-Based Biomarkers in Pancreatic Cancer and Biliary Tract Cancers
In this study, the role of miRNAs has been assessed in a large cohort of pancreatic cancer.
Poster
Is Oxford Nanopore Technology Ready for Clinical Diagnostics?
Our objective is to validate diagnostic services using Oxford Nanopore’s Minion in the first instance and to evaluate the cost and performance compared to existing sequencing technology in areas such as tumour DNA sequencing (and circulating tumour DNA), virology, microbiology, genetics and HLA-typing.
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