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Double helix structure of DNA.
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Ancestral Differences Affect Performance of CRISPR-Cas9 Guides in Human Cells

New research shows that many of these CRISPR screening experiments rely on components, called CRISPR/Cas9 guides, that do not perform equally well in cells from people of all ancestries, which can cause CRISPR screens to miss cancer dependencies.
A puzzle that spells the word autism.
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Brain Cell Overgrowth Before Birth Associated With Autism Severity

Brain organoids derived from toddlers with autism spectrum disorder suggest that subtypes of the condition may have in utero origins. That's according to a new study from researchers at the University of California San Diego, led by Dr. Alysson R. Muotri.
Cancer cells.
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AI Spots Cancer Months Before Standard Methods

An artificial intelligence-powered method for detecting tumor DNA in blood has shown unprecedented sensitivity in predicting cancer recurrence, in a study led by researchers at Weill Cornell Medicine.
A clinician applies a band aid to a vaccination site.
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Mandated Flu Shots for Staff Are Now Required by More Hospitals

In just a few months, hospitals and health systems nationwide will start working to vaccinate as many staff as possible against the flu, and more US hospitals than ever will require employees to get vaccinated.
An infant sleeping.
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Early Temperature Exposure Linked to Brain White Matter Development

New study underscores the vulnerability of foetuses and children to cold and heat, and the need to protect the most vulnerable communities from the effects of climate change.
An old couple at the beach.
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Genetic Blueprint Influences Women's Cellular Response to Aging

A genomic analysis co-led by NIH suggests that the DNA a woman is born with may influence how her cells respond to chromosomal abnormalities acquired with aging.
A 3D model of human lungs.
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Distinct Bacterial Communities Identified in Patients With Cystic Fibrosis

Chronic lung diseases are often accelerated and exacerbated by polymicrobial infections. An international study team led by MedUni Vienna has identified two types of these so-called dysbioses in cystic fibrosis.
A girl sitting on a chair looking out a window.
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Depression and Memory Are Closely Interrelated, Study of 8,268 People Finds

Depressive symptoms are linked to subsequent memory decline in older people, while poorer memory is also linked to an increase in depressive symptoms later on, according to a new study led by researchers at UCL and Brighton and Sussex Medical School.
A mother and her baby.
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Digital Babies Created To Simulate the First 180 Days of Life

Whole-body models (WBMs) are computational models that integrate different types of multiomics data such as genomic, metabolic and proteomic insights, and have been created to simulate and study adult physiology and disease. WBMs for newborns, however, are currently lacking – until now.
A scientist places test tubes containing blood into a test tube rack.
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Patients With Schizophrenia Are Three Times More Likely To Have Bartonella DNA in Their Blood

A new study has found that patients diagnosed with schizophrenia or another psychotic disorder are three times more likely to have Bartonella DNA in their blood.
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