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Ancestral Differences Affect Performance of CRISPR-Cas9 Guides in Human Cells
New research shows that many of these CRISPR screening experiments rely on components, called CRISPR/Cas9 guides, that do not perform equally well in cells from people of all ancestries, which can cause CRISPR screens to miss cancer dependencies.
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Brain Cell Overgrowth Before Birth Associated With Autism Severity
Brain organoids derived from toddlers with autism spectrum disorder suggest that subtypes of the condition may have in utero origins. That's according to a new study from researchers at the University of California San Diego, led by Dr. Alysson R. Muotri.
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AI Spots Cancer Months Before Standard Methods
An artificial intelligence-powered method for detecting tumor DNA in blood has shown unprecedented sensitivity in predicting cancer recurrence, in a study led by researchers at Weill Cornell Medicine.
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Mandated Flu Shots for Staff Are Now Required by More Hospitals
In just a few months, hospitals and health systems nationwide will start working to vaccinate as many staff as possible against the flu, and more US hospitals than ever will require employees to get vaccinated.
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Early Temperature Exposure Linked to Brain White Matter Development
New study underscores the vulnerability of foetuses and children to cold and heat, and the need to protect the most vulnerable communities from the effects of climate change.
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Genetic Blueprint Influences Women's Cellular Response to Aging
A genomic analysis co-led by NIH suggests that the DNA a woman is born with may influence how her cells respond to chromosomal abnormalities acquired with aging.
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Distinct Bacterial Communities Identified in Patients With Cystic Fibrosis
Chronic lung diseases are often accelerated and exacerbated by polymicrobial infections. An international study team led by MedUni Vienna has identified two types of these so-called dysbioses in cystic fibrosis.
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Depression and Memory Are Closely Interrelated, Study of 8,268 People Finds
Depressive symptoms are linked to subsequent memory decline in older people, while poorer memory is also linked to an increase in depressive symptoms later on, according to a new study led by researchers at UCL and Brighton and Sussex Medical School.
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Digital Babies Created To Simulate the First 180 Days of Life
Whole-body models (WBMs) are computational models that integrate different types of multiomics data such as genomic, metabolic and proteomic insights, and have been created to simulate and study adult physiology and disease. WBMs for newborns, however, are currently lacking – until now.
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Patients With Schizophrenia Are Three Times More Likely To Have Bartonella DNA in Their Blood
A new study has found that patients diagnosed with schizophrenia or another psychotic disorder are three times more likely to have Bartonella DNA in their blood.
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