Latest App Notes & Case Studies

This application note demonstrates the successful identification of two low-abundance monoclonal antibodies using next-generation protein sequencing.

Oligonucleotides play a crucial role in modern drug development, therefore their accurate characterization is essential. However, given the sheer complexity and diversity of the types of oligonucleotides that are in clinical development, a range of diverse analytical approaches are necessary.

This application note compares the use of pulsed- and constant-field technologies to support researchers in choosing the most suitable automated instrument for their sequencing workflow.

This technical overview highlights the latest fragment analysis and electrophoresis solutions for adapter dimer detection. It explores how greater detection and resolution capabilities can support sequencing efficiency and quality control (QC).

Microbial whole-genome sequencing (WGS) can support taxanomic classification, functional characterization and identify anti-microbial resistance in diverse sample types. It can provide greater resolution and more quantitative insights compared to shotgun and 16S methods.

The 16S ribosomal RNA (16S rRNA) gene is present in most bacterial species. As it contains both highly conserved and variable regions, it can be used to identify and classify different taxonomic levels.

Studying DNA methylation at correlated gene regions can provide researchers with insights into disease-associated epigenetic variation. Hence, cost-effective sequencing is essential for our advancement and understanding of epigenetic epidemiology.

Target enrichment allows researchers to selectively capture, sequence and study specific genes or genomic regions. Carefully designed target enrichment probes that hybridize with high specificity and coverage are essential to ensuring workflow efficiency and data quality.

The ability to study transcript isoforms in detail could have a significant impact on our understanding of health and disease. However, most commonly, bulk sequencing is the selected method that only provides an average of the transcripts expressed across your sample of cells.

The scale of research into potential gene therapies often means that work is distributed across multiple locations. Investigators must have confidence that the results obtained at one site are consistent with results obtained at other sites participating in the study.